The Cosmic Cocktail of Exoplanet Atmospheres

Scientists have conducted the first lab experiments on haze formation in simulated exoplanet atmospheres, an important step for understanding upcoming observations of planets outside the solar system with the James Webb Space Telescope.

The simulations are necessary to establish models of the atmospheres of far-distant worlds, models that can be used to look for signs of life outside the solar system. Results of the study appeared recently in Nature Astronomy.

“One of the reasons why we’re starting to do this work is to understand if having a haze layer on these planets would make them more or less habitable,” says the paper’s lead author, Sarah Hörst, assistant professor in the Krieger School’s Department of Earth and Planetary Sciences.

With telescopes available today, planetary scientists and astronomers can learn what gases make up the atmospheres of exoplanets.


Sarah Hörst and assistant research scientist Chao He examine samples of simulated atmospheres in a dry nitrogen glove box.


“Each gas has a fingerprint that’s unique to it,” says Hörst. “If you measure a large enough spectral range, you can look at how all the fingerprints are superimposed on top of each other.”

Current telescopes, however, do not work as well with every type of exoplanet. They fall short with exoplanets that have hazy atmospheres. Haze consists of solid particles suspended in gas, altering the way light interacts with the gas. This muting of spectral fingerprints makes measuring the gas composition more challenging.

Hörst believes this research can help the exoplanet science community determine which types of atmospheres are likely to be hazy. With haze clouding up a telescope’s ability to tell scientists which gases make up an exoplanet’s atmosphere—if not the amounts of them—our ability to detect life elsewhere is a murkier prospect.

Planets larger than Earth and smaller than Neptune, called super-Earths and mini-Neptunes, are the predominant types of exoplanets, or planets outside our solar system. As this class of planets is not found in our solar system, our limited knowledge makes them more difficult to study.

With the launch of the James Webb Space Telescope scheduled for 2020 (see p. 34), scientists hope to be able to examine the atmospheres of these exoplanets in greater detail. JWST will be capable of looking back even further in time than the Hubble Space Telescope can, with a light-collecting area around 6.25 times greater than Hubble’s. Orbiting around the Sun a million miles from Earth, JWST will help researchers measure the composition of extrasolar planet atmospheres and even search for the building blocks of life.

“Part of what we’re trying to help people figure out is basically where you would want to look,” says Hörst of future uses of the James Webb Space Telescope.

Given that our solar system has no super-Earths or mini-Neptunes for comparison, scientists don’t have “ground truths” for the atmospheres of these exoplanets. Using computer models, Hörst’s team was able to put together a series of atmospheric compositions that model super-Earths or mini-Neptunes. They assembled nine different “planets” by varying levels of three dominant gases: carbon dioxide, hydrogen, and gaseous water; four other gases: helium, carbon monoxide, methane, and nitrogen; and three sets of temperatures.

The computer modeling proposed different percentages of gases, which the scientists mixed in a chamber and heated. Over three days, the heated mixture flowed through a plasma discharge, a setup that initiated chemical reactions within the chamber.

“The energy breaks up the gas molecules that we start with. They react with each other and make new things, and sometimes they’ll make a solid particle [creating haze] and sometimes they won’t,” Hörst says.

She added: “The fundamental question for this paper was: Which of these gas mixtures—which of these atmospheres—will we expect to be hazy?”

The researchers found that all nine variants made haze in varying amounts. The surprise lay in which combinations made more. The team found the most haze particles in two of the water-dominant atmospheres.

“We had this idea for a long time that methane chemistry was the one true path to make a haze, and we know that’s not true now,” says Hörst, referring to compounds abundant in both hydrogen and carbon.

Furthermore, the scientists found differences in the colors of the particles, which could affect how much heat is trapped by the haze.

“Having a haze layer can change the temperature structure of an atmosphere,” Hörst says. “It can prevent really energetic photons from reaching a surface.”

Like the ozone layer that now protects life on Earth from harmful radiation, scientists have speculated a primitive haze layer may have shielded life in the very beginning. This could be meaningful in the search for external life.

For Hörst’s group, the next steps involve analyzing the different hazes to see how the color and size of the particles affect how the particles interact with light. They also plan to try other compositions, temperatures, and energy sources to examine the composition of the haze produced.

“The production rates were the very, very first step of what’s going to be a long process in trying to figure out which atmospheres are hazy and what the impact of the haze particles is,” Hörst says.

Philosophy Matters

Legendary investor William H. “Bill” Miller III has committed a record $75 million to the Krieger School’s Department of Philosophy to broaden and intensify faculty research, graduate student support, and undergraduate study of philosophical thought.

Miller, founder and chairman of Miller Value Partners and formerly the longtime, highly successful manager of the Legg Mason Capital Management Value Trust, is himself a former Johns Hopkins philosophy graduate student.

“I attribute much of my business success to the analytical training and habits of mind that were developed when I was a graduate student at Johns Hopkins,” says Miller, who is best known for beating the Standard & Poor’s 500 with his Legg Mason fund for a record 15 consecutive years, from 1991 to 2005.

“I am delighted to be able to show my gratitude by helping to move the department to its rightful place among the best in the country,” he says.

Ronald J. Daniels, president of Johns Hopkins University, says Miller’s aim—and the university’s—is to set a new standard for excellence in philosophy and promote powerful, change-making collaboration between philosophers and other scholars.

“Philosophy matters,” Daniels says. “Philosophy defines what it is to be human, to lead lives that are meaningful, and to create societies that are just and humane. The contemporary challenges of the genomics revolution, the rise of artificial intelligence, the growth in income inequality, social and political fragmentation, and our capacity for devastating war all invite philosophical perspective. Bill Miller’s unprecedented commitment to our Department of Philosophy underscores the continuing vitality and relevance of the humanities.”

The university is recognizing Miller’s generosity by renaming the department in his honor.

“Bill’s dual perspective as a business leader and an intellectually curious lifelong student of philosophy is so important,” says Beverly Wendland, dean of the Krieger School. “Our talented faculty and the students who will study in the William H. Miller Department of Philosophy for generations to come will always be grateful, as I am, for Bill’s confidence in Johns Hopkins.”

Miller’s gift will help grow the department within 10 years to 22 full-time faculty members from its current 13. It will create an endowed professorship for the chair of the department, eight other endowed professorships,and endowed support for junior faculty members.

The gift will add $10 million to endowed support for philosophy graduate students and postdoctoral fellows. The university also aims to attract more undergraduates to the study of philosophy, in part through new introductory courses and additional interdisciplinary tracks.

“The study of philosophy has been central to Johns Hopkins from the university’s beginning in 1876,” says Richard Bett, professor and chair of the department. “Bill Miller knows that every student, no matter their major or intended career, can benefit from philosophical study.”

Snapshot: From the Office of Karen Fleming

Svedberg invented the analytical ultracentrifuge, and that’s my background—ultracentrifugation. The design is a combination of science and art—it’s an accessible beauty. These are fundamental physics and chemistry concepts, but you don’t even have to know anything about science to look at it and think it’s cool.”
Karen Fleming, Professor, Department of Biophysics

Theodor Svedberg won the Nobel Prize in chemistry in 1926 for inventing the analytical ultracentrifuge, a tool that measures the size of molecules. But he also had an artistic side. In 1955, when he couldn’t find suitable fabric for new drapes for the Gustav Werner Institute, he simply designed his own. At a 2009 conference in Sweden commemorating the 125th anniversary of Svedberg’s birth, Professor Karen Fleming and her colleagues were each given a single black linen square with renderings of subatomic concepts like a Bohr orbital, mass spectrometry, or a Schrödinger atom—remnants of Svedberg’s remarkable curtains. Fleming was so taken with the fabric that she found a company that still manufactured it, and ordered several yards. “Atomics” now lines the bookcase in her office.

Evidence Points to Cooling Property of Dark Matter

A new measurement recently reported in Nature provides evidence for a new cooling property of dark matter previously posited by a collection of JHU professors, postdoctoral fellows, and students.

The paper, authored by a group of radio-astronomers at Arizona State University, describes the first measurement of the temperature of intergalactic hydrogen atoms from only 180 million years after the Big Bang.

Surprisingly, that temperature reading is colder than expected in the standard cosmological model. An interpretation paper by a researcher at Tel Aviv University explains that this result can be understood if these hydrogen atoms have some small heat exchange with the abundant dark matter in the universe. If this result is correct, it tells us something new about the physics of dark matter: Not only does dark matter have a gravitational pull that prevents galaxies from flying apart, it also has the ability to absorb heat energy.

The theoretical research that suggested hydrogen might be cooled by dark matter, and thus produce the signal reported in Nature, was conducted at the Krieger School of Arts and Sciences.

The initial paper exploring the possibility of heat exchange between hydrogen and dark matter was authored in 2013 by Marc Kamionkowski, the William R. Kenan Professor and a theoretical physicist in the Department of Physics and Astronomy, and two of his collaborators. Two subsequent papers elaborated further this heat exchange and proposed to seek evidence for it in precisely the type of measurements reported in Nature. One of these papers was authored by Joseph Silk, a research professor in the department, and his collaborators; the other paper was written by JHU postdocs Yacine Ali-Haïmoud and Ely Kovetz and a graduate student, Julián Munoz.

“This newly reported result, if confirmed by subsequent measurements, may well turn out to be a Rosetta stone for the nature of dark matter,” Kamionkowski said. “Joe and his collaborators, and Julian, Ely, and Yacine, deserve significant credit for suggesting these neutral-hydrogen measurements could be used in this way.”

The Center for Visual Arts

Established in 1974 as The Homewood Art Workshops, the center was an informal opportunity for Hopkins students, regardless of experience, to learn the fundamentals of drawing and painting. Eugene Leake, renowned painter and former president of the Maryland Institute College of Art, was the program’s first director.

Fast-forward to today. The center* has grown exponentially in popularity, offering courses in drawing, painting, photography, cartooning, sculpture, and printmaking. A dedicated space in the Mattin Center has become a hub for the visual arts, and students can now declare a minor in visual art.

Here, Craig Hankin—who is retiring this year after more than 30 years directing the program—gives artistic advice to senior student Amy He.

By the Numbers:

  • # of years the art program has been in existence – 44
  • # of courses offered in a given semester – 14+
  • # of faculty teaching at the center – 10
  • # of students taking visual arts courses in a given semester – 165

*On its 40th anniversary, and for the first time offering a minor in visual art, the Homewood Art Workshops became the Center for Visual Arts, a name more accurately reflecting its role on the Hopkins campus.

Major Infatuation: Art History

As an art historian, I believe brushstrokes on canvas reveal stories of history in a way that the written or spoken word cannot. When I study art history, I become Marty McFly. With so many years of art history all around me, I am able to travel to the past and then back to the future.”

Maya Kahane ’19


Art is incredibly intimate and spurs many different emotive responses. Artworks can illuminate both an artist’s soul and the psyche of the viewer.”

Tess DeBerry ’19


Art history is like poetry in many ways. Where one describes with words, the other with dabs of paint. Studying art history has made me much more detail-oriented. I now notice tiny details in everything. If I were to describe my major I would say: EVERYTHING is art.”

Sydney Baker ’18


New Bloomberg Professor Named

Vesla Weaver, a leading scholar on racial politics and criminal justice issues in America, joined Johns Hopkins last fall as a Bloomberg Distinguished Associate Professor in political science and sociology. She is perhaps best known as a leader in the movement to push the social sciences to understand punishment as a crucial site of governance in the U.S., as well as a forceful mechanism of racial inequity. With her research, she has informed one of the central questions facing policymakers today: how to grapple with the consequences of nearly four decades of state-enforced discipline for citizens and communities.

In the early years of her graduate studies at Harvard, Weaver bucked against the common thinking that punishment was not a core concern for political science, successfully arguing that incarceration and surveillance influenced America’s post-war institutions in ways that critically altered the racial politics and inequality of later decades.

Later, as a professor at Yale, Weaver embarked on the first large-scale empirical study of how seismic shifts in incarceration and policing shaped the political and civic realities in the communities most affected.

Weaver received her undergraduate degree in government studies from the University of Virginia. She earned a doctoral degree in government and social policy from Harvard, where she also worked on the university’s Civil Rights Project.

In 2012, Weaver became a tenured associate professor in African-American studies and political science at Yale.

Tracks: Claire Iverson

Following her passion from Homewood to Peabody and back

Claire Iverson ’20, dual degree in international studies and voice, fell in love with opera in her junior year of high school. In order to follow her passion, the Baltimore native (and Baltimore School for the Arts graduate) manages a staggering 12 classes a semester: four to five classes at Homewood and six to seven at Peabody. She has performed with the Peabody Opera Theatre and works part time on weekends as a singer at St. Jane Frances de Chantal Catholic Church in Pasadena, Maryland. Next fall, Iverson will study music in Milan, home of Italy’s famed opera house, La Scala.

Curriculum Vitae: Caleb Deschanel

Photo of Caleb Deschanel by Phil Konstanin

Education

  • 1966 Bachelor’s degree, liberal arts, Johns Hopkins University
  • 1968 Master’s degree, film studies, University of Southern California School of Cinematic Arts
  • 1969 Cinematography fellow, American Film Institute

Notable

  • He has been nominated for five Academy Awards.
  • In 2010, he was given a Lifetime Achievement Award from the American Society of Cinematographers.
  • In 2014, he was given a Lifetime Achievement Award from Poland’s Camerimage Film Festival.
  • His introduction to photography came at the age of 11, when he received a Brownie Hawkeye camera
  • He was inspired by Hopkins professors such as Dick Macksey, who involved Deschanel and other students in producing a 16mm film for a class, and Chaplain Emeritus Chester Wickwire, who organized on-campus screenings of art films.
  • While at Johns Hopkins, Deschanel was the co-editor and photographer for Johns Hopkins News-Letter and a photographer for the yearbook.

Films
(a sample)

  • The Black Stallion (1979)
  • Being There (1979)
  • The Right Stuff (1983)
  • The Natural (1984)
  • Fly Away Home (1996)
  • Hope Floats (1998)
  • The Patriot (2000)
  • The Passion of the Christ (2004)
  • My Sister’s Keeper (2009)
  • Winter’s Tale (2014)
  • Unforgettable (2017)

Television

  • Twin Peaks
  • Law & Order: Trial by Jury, Conviction
  • Bones

In His Own Words

“Movies at their best can inspire us to be better human beings. Any great literature does the same thing—gives us insight and understanding of people and a different perspective on life—so why should film be different?”
Markee 2.0 Magazine

“To make a movie, you have to have an incredible drive and enthusiasm for something.”
Hollywood Reporter

“Look at visual images as much as you can, whether it’s paintings, photographs, or movies, and shoot as much as you can. I’m still learning every time I shoot a frame of film. When I’m not learning, I will know that it’s time to quit.”
—Caleb Deschanel’s advice to aspiring filmmakers

New Bloomberg Professors Named

The Krieger School of Arts and Sciences is proud to welcome two new Bloomberg Distinguished Professors to its ranks.

photo of Chris CannonChris Cannon, a scholar of linguistics and literacy and one of the world’s leading experts on 14th-century poet Geoffrey Chaucer—joined Johns Hopkins as the 31st Bloomberg Distinguished Professor. He has appointments in the Krieger School’s Department of English and the Department of Classics.

Cannon received his undergraduate, graduate, and doctoral degrees from Harvard. He comes to Hopkins from New York University, where he chaired the Department of English for five years.

In the world of medieval literature and linguistics, Cannon is a self-described “anti-foundationalist.” He digs down into bedrock understandings within these scholarly areas, and then challenges them.

Cannon is the author of four books, including, most recently, From Literacy to Literature: England, 1300-1400. He is currently co-editing with Harvard’s James Simpson a revision of the 19th-century edition of all of Chaucer’s works by W.W. Skeat. He is also working on a fifth monograph that explores how literacy and oral traditions intersect, and particularly the role that dictation played in writing and the circulation of books during the Middle Ages.

Literacy and education during the Middle Ages is an area of particular interest for Cannon, and especially the history of childhood reading in medieval England. In addition to teaching undergraduate courses, he is expected to contribute a humanistic element to the Johns Hopkins Science of Learning Institute.

photo of Rachel GreenRachel Green, a biologist and geneticist with the Johns Hopkins School of Medicine, will use her new appointment to establish new connections to the Krieger School’s Department of Biology. Her work involves researching the cellular structure of the ribosome. The laboratory she leads at Hopkins is devoted to this complex macromolecular machine, investigating and manipulating its roles in protein expression.

Green arrived at Johns Hopkins in 1998, joining the Department of Molecular Biology and Genetics.

She conducted her graduate studies at Harvard University, working in the lab of Jack Szostak, who was focused on replicating the elements of “the RNA World”—the primordial environment in which scientists believe early forms of life may have relied solely on RNA to store genetic information and catalyze chemical reactions.

That led her to ribosome. While working in the lab of Harry Noller for her postdoctoral fellowship at the University of California, Santa Cruz, she investigated the ribosome’s role at the crossroads between the ancient and modern worlds, translating RNA messages into protein.

Green’s research has focused on the ribosome’s role in translating the genetic information found in all cells. Initially, her work investigated the most fundamental aspects of ribosome function in the bacterial ribosome. More recently, she has focused on quality control steps imposed on the translational process in eukaryotes.

These areas are critical for understanding the natural world and for their medical relevance, Green says. For example, her work on ribosome rescue and homeostasis sheds light on certain blood disorders and genetic diseases.

Works in Progress (Fall 2017)

A glimpse at ongoing faculty research

photo of Nuruosmaniye mosque

“Reading” Buildings as Documents

For six centuries, the Ottoman Empire was a major geopolitical power, straddling portions of Africa, Asia, and Europe. And for most of that time, the empire was at war with its rivals.

Following a military victory in Belgrade in 1739, the Ottomans enjoyed a prolonged peace with the West. Commemorating the event by building a structure deemed the Nuruosmaniye Mosque, the victors appropriated some of the aesthetics of their foes. The name given to that architectural style: Ottoman Baroque.

The commentators who coined the term meant it disparagingly—suggesting that it was a foreign style imposed on a weakened empire. Modern-day scholars have avoided the label, sensitive to the political commentary it encapsulated.

But Ünver Rüstem, an assistant professor in the Department of the History of Art, who specializes in Islamic art and architecture, says it is time to embrace the term Ottoman Baroque for what it was—a cross-cultural borrowing of aesthetics no less worthy than any comparable adaptations by Western artists. In fact, he says, the style was a “political statement of the Ottoman wherewithal, authority, and reach.”

The topic of his doctoral thesis, Ottoman Baroque, is the subject of a new book Rüstem has written, expected to be published in early 2019.

The Baroque movement itself hasn’t fared well from a modern-day perspective. Its ornate, complex style seems cluttered and superfluous when juxtaposed against the simple, efficient lines of the mid-20th century and beyond. But the style’s details—extensive references to natural objects such as shells and leaves, as well as rounded and undulating arches—were much admired in many regions of the world where the Baroque took hold and was lavishly implemented in the Nuruosmaniye Mosque and subsequent buildings.

While the Ottomans were accomplished builders, they weren’t big on explaining their work. No records of significance detail what exactly they had in mind when switching from the more sober architecture of previous centuries to the Baroque style. So Rüstem has had to do a lot of extrapolation based on what can be observed.

“I’m looking at the buildings themselves as documents,” he says. Their structures and surfaces “are a visual representation of a much larger shift in the empire.”

He’s made annual visits to Istanbul to do his research, but not without challenges. He arranged to spend an academic year in Istanbul, only to learn that the Nuruosmaniye Mosque was to be closed for repairs for the duration of his visit. In subsequent trips he returned to the mosque, hoping to learn as much as possible.

 


A Deep Dive into American Democracy

In 2015, Robert Lieberman, the Krieger-Eisenhower Professor in political science, was sitting on a panel at the American Political Science Association’s annual meeting when an attendee stood up and asked: “Have any of you ever considered the possibility of a regime change in the United States?” Lieberman and his colleagues on the panel were at a loss. They hadn’t examined under what conditions democracy in the United States might falter. “We all kind of looked at our shoes,” he says.

But after witnessing the outcome and aftermath of the 2016 presidential election, Lieberman has been much more aware of potential cracks in the foundation of U.S. democracy. “It’s not that we’re predicting that American democracy is in mortal peril, but some of the basic tenets of a liberal democracy that we all take for granted, like separation of powers, a free press, the validity of elections, are all of a sudden under some challenge,” he says.

In the months since the election, Lieberman and several colleagues in political science at Swarthmore College and Cornell University have been examining the causes—and consequences—of what Lieberman dubs “Trumpism,” both in this country and in similar populist movements abroad. The result is the American Democracy in Historical and Comparative Perspective project, which the academics hope to use as a basis for a series of public discussions to be held in Washington, D.C., in the coming months.

Lieberman says the idea is not to attack President Donald Trump, but to try to understand how the rise in anti-immigration, anti-globalism, and economic inequality have fueled the populist movement, and whether it’s potentially a lasting trend.

“The question is, what is it about this particular configuration of circumstances that made it possible for a candidate like Trump to win, and, number two, why does it seem like this episode of anti-liberalism is more threatening than other episodes in the past?”

Lieberman compares the current environment in some ways to the Industrial Revolution of the late 18th and early 19th centuries, when economic transformation reorganized the structure of society. That, he says, led to a generation or more of redefining political norms. Could we be living in a similar situation today?

Lieberman and his colleagues hope their project generates a healthy discussion, and ultimately, a better understanding of geopolitical conditions reshaping the world. “American democracy is a very resilient system,” he says.

 


The Weather in Space

While scientists have gained a decent understanding of the atmospheres surrounding other planets in our solar system—including chemical composition, density, and prevalence of clouds, haze, and dust—they know little about the billions of other planets scattered across the universe. (Yes, billions. The Kepler Space Telescope convinced astronomers in 2014 than there are more planets than stars in the universe.)

Given that the closest of such bodies (called exoplanets) are a couple of light years away, satellite reconnaissance is out of the question. To fill in the gaps, we have places such as Assistant Professor Sarah Hörst’s research lab in the Department of Earth and Planetary Sciences.

Hörst simulates atmospheric chemistry in her lab. “We take a 2-liter container, fill it with the gas mixture that would be found on a given planet, adjust the temperature, then zap it with an energy source, such as a lamp that produces ultraviolet photons,” she says. (The energy source affects the elements inside the container much as a nearby star would.)

“What results is an idea of what such an atmosphere would look like—from thin and clear to thick and opaque.”

Cumulatively, she’s essentially compiling a database of atmospheric outcomes. Such information is helpful in the short term for astronomers who want an idea of whether a given exoplanet is worth focusing on—literally. An impenetrably hazy atmosphere would be more limiting in learning about the exoplanet’s features than one with a clear one.

While the planets in our solar system have dramatically different atmospheres than the Earth (clouds made up of methane, ammonia, or nitrogen, for example), our neighbors can tell us only a fraction of the story about atmospheric properties.

“They emerged in the same conditions as each other, and so they represent a very limited set of information on how planets can form,” Hörst says. “We have a theoretical framework for atmospheric formation, but we haven’t been able to test it previously.”

The looming question over the properties of other planets, of course, is whether they could sustain life.

SaveSave

Field Notes

Learned Scribbles

Junior Anna-Astrid Oberbrunner spent a good chunk of last summer holed up in a windowless room with “a beautiful and fascinating object.” That’s how she describes a copy of Virgil’s works printed in Venice in 1507 that was recently added to the university’s rare book collection. Though worms have gnawed tiny holes here and there and at some point over the centuries the tome ignobly did duty as a drink coaster (at least, the ring stains suggest as much), for a classics major who’s been studying Latin since high school, the hoary volume is mental catnip.

“It’s always cool to work with an artifact,” says Oberbrunner, recipient of a Dean’s Undergraduate Research Award. “This is kind of the perfect project for me because it’s translation but it’s also, in a sense, archaeology.”

But she’s not interested so much in the printed words of the ancient Roman poet who died more than 2,000 year ago, but rather the handwritten annotations accompanying them. There are notes in various hands scrawled in the margins and even doodles throughout the book. (Picture the condition of a used English lit anthology making the rounds today, minus the yellow highlighting.) Of particular interest are some 20 pages of tightly scrawled Latin sewed into the front of the book and attributed to Benedictus Philologus, a 16th-century Florentine scholar.

“It’s unclear how the inserted pages actually relate to the book itself, which is going to be one of the things I try to figure out,” she says. “As far as we know, they’ve never been translated.”

Her first task has been to transcribe all the handwriting into her computer, a challenge because the author used all manner of abbreviations and verbal shortcuts that have to be figured out. The process of translating the Latin into English is ongoing. “I’d like to understand who was using the book and for what,” Oberbrunner says. “Was it a teaching tool? Did it belong to some scholar who was using it for his work? Is this a personal copy?”

Figuring out what Philologus and the others who penned notes and commentary in the book were saying about Virgil’s Aeneid and his other pre-Christian writings will hopefully also say something about the Renaissance era in which they wrote them. “It’s like looking into like a funhouse mirror,” Oberbrunner says. “You can see what this person is thinking reflected in what they thought was interesting to them about antiquity.”


Saving Memories

photo of Ansh Bhammar '18Ansh Bhammar (left) spent a couple of summers during high school as a recreational therapy volunteer at a VA hospital in his native Boston. He specifically worked with Alzheimer’s patients, engaging them in a range of activities: playing catch, taking walks, reading, doing puzzles.

“Working with veterans, I would hear some incredible stories,” the junior neurology major says. But there was a sadness to it all as well. These patients—most in their 70s and 80s—had profound cognitive impairment. “They wouldn’t remember me or my face, and I would always have the same conversation with the same people,” Bhammar says. “They’d be happy to see a new face even though they’ve been seeing me every day for two months.” And Alzheimer’s—now the sixth leading cause of death in the country—is degenerative and fatal.

This interest in seniors, combined with a long fascination with the human brain—what Bhammar calls, “a universe saturated with mysteries”—has him aiming for a career in geriatric neurology. And it’s also why he’s doing research in Professor Michela Gallagher’s lab in the Department of Psychological and Brain Sciences, which is focused on neurocognitive aging. His research is made possible with support from the Phyllis F. Albstein Fund.

In the lab, Bhammar no longer works with seniors, but instead, with rats standing in for humans. The rodents are separated into three categories: young rats, older rats that don’t show any cognitive impairment, and older rats that do show impairment. (The rodents are subject to a memory test of sorts in a pool of water to determine their cognitive state.) It’s Bhammar’s job to examine the thinly sliced brains of all three types of rats looking for differences across the groups.

What to look for? Well, our brains operate with a balance between neural excitation (a lot of synaptic activity) and inhibition (reduced synaptic activity). Might age-related cognitive impairment be the result of an excitation/inhibition imbalance? Gallagher’s most significant finding to date suggests as much, as she’s shown that excessive hyperactivity in one section of the hippocampus may account for memory loss. Bhammar examines brain slices that have been dyed to make the presence of certain genes stand out—genes whose presence in small amounts or greater amounts model whether a section of the brain was subject to excitation or inhibition. So far, preliminary findings indicate that brains of older rats without cognitive impairment show increased neural inhibition.

“This is all a hypothesis at this point, but in order to maintain successful cognition you may need to increase the amount of inhibition in certain areas of the brain,” Bhammar says. “When those ratios go haywire—that’s what could lead to cognitive impairment. But we’ve got a long way to go before we can actually conclusively say that.”


Rice to the Rescue

photo of Serwah Afranie '18Sophomore Serwah Afranie (left) has been interested in the healthy properties of rice since high school. That’s when she saw a segment of ABC’s World News Tonight program discussing an Asian community with very low instances of breast cancer. Did their rice-based diet play a role?

Rice was certainly a mealtime staple for Afranie growing up in her native Ghana, with dishes like spicy rice jollof and the rice-and-beans combo, waakye. “I’ve eaten rice for breakfast, lunch, and dinner before,” she says. It led her to write a 17-page literature review in her senior year of high school that examined potential chemopreventive properties of rice and how a rice diet might reduce breast cancer risk.

“I found that there are some properties in rice that do reduce breast cancer risk,” says Afranie, who also noticed that Africa—like Asia—has both higher rice consumption and lower rates of breast cancer compared with North America. Now double majoring in public health and international studies, she’s hoping she can take her rice research to the next level.

Her research project is still in the early stages, though as a first step she’s narrowed the focus to look at the grain’s ability to lower estrogen levels. (Studies have shown that higher levels of estrogen in the blood can increase breast cancer risk.) Over the next couple of years she wants to travel to Asia and Africa and establish a dietary study.

“I will set up test groups of women where I can measure their diets,” says Afranie, recipient of a Woodrow Wilson Fellowship. “Basically, I’ll have these groups consume brown rice for a couple of weeks while I measure their estrogen levels over time to see if the consumption of rice is limiting estrogen production or estrogen circulation in the body.”


China Courts Africa

photo of Leandre Eberhard ’18For the past decade, China has poured billions into Africa—investing in companies, buying land, and bankrolling all manner of infrastructure projects, from railroads to cell phone networks to ports and pipelines. At first blush, it’s easy to see how the manufacturing powerhouse would be eager to get increased access to raw materials and agricultural goods, while also positioning the second most populous continent to be a ready market for its container ships of goods.

Senior Léandre Eberhard (left), finishing up an extra semester so he can add a math major to his others (economics, international studies, and German), wondered if there was more to the story. He used funds from a Woodrow Wilson Fellowship to find out.

“What I want to quantify is if Chinese investment in Africa creates more commerce overall between African countries and the world,” he says.

Eberhard wrote a statistical computing program using the programming language R. It uses a least absolute shrinkage and selection operator—a type of regression abbreviated to LASSO—designed to weed through the reams of trade and investment data available from the World Bank and Chinese Ministry of Commerce.

“LASSO is actually a technique that I learned in a class last semester called Big Data,” Eberhard explains “Essentially, what it does is it selects variables for you. And using that gives you more measurable data you can actually interpret.”

So far he’s found that Chinese investment does not appear to increase African trade with other nations. “The current results seem to support the standard opinion that people have in the West that Chinese investment in Africa is mostly benefiting China.” One acknowledged potential shortcoming to his finding might be its use of only six years of trade data, from 2004 to 2010. But the beauty of his research is that it created a tool he can now use for other purposes.

“The hard part is done,” he says. “The code is written so all I have to do now is give it new data.” He’s already working on feeding the program data about Chinese investments in Pakistan and the Middle East.

Eberhard has found the process of self-guided research was reward in itself.

“It’s just so different from class work where you’re given an assignment and you just finish that and then you’re done with it,” he says of his research. “You have to make your own assignments and ask questions of yourself without knowing if there’s a correct answer. I’m really glad that I’m able to do this before actually being a graduate student or a PhD student.”