Alumni Kudos: Spring 2021

Michael H. Cohen ’62 was a 2019 recipient of the Ellis Island Medal of Honor for career achievement in medicine.  

Peter S. Conti ’78, a professor of radiology and director of the Molecular Imaging Center at the University of Southern California, was awarded the 2020 Benedict Cassen Prize by the Society of Nuclear Medicine and Molecular Imaging.  

George R. Cotter ’71 MS was inducted into the National Security Agency Cryptologic Hall of Honor in 2020.  

Michael Lavers ’10 MFA is the winner of the Bridport Prize poetry competition. 

Joanna Pearson ’09 MFA is the 2021 winner of the Drue Heinz Literature Prize for her collection of short stories, Now You Know It All.  

Steven F. Rubin ’78 was the recipient of the 2019 Lifetime Achievement Award from the American College of Osteopathic Family Physicians.  

Alan Sorkin ’63, ’64 MA, ’66 PhD, professor emeritus at the University of Maryland, Baltimore County, received the Johns Hopkins Alumni Association’s 2019 Heritage Award for exceptional and devoted service.  

Slavery and Restitution

It was 1848, 15 years before President Abraham Lincoln would issue his Emancipation Proclamation, and former slave Henrietta Wood finally had her freedom papers. 

But what Wood would later term her first “sweet taste of liberty” living as a free woman in Cincinnati only lasted until 1853, when a corrupt Kentucky deputy sheriff crossed the Ohio River, kidnapped Wood, and sold her back into slavery. The abduction set into motion a series of events that culminated in Wood suing the sheriff, by then a wealthy businessman, and being awarded a stunning $2,500 in damages in 1878. It was the largest known sum ever awarded in an American court in restitution for slavery. 

Caleb McDaniel headshot
Caleb McDaniel
[Photo: Christina Tan]

Wood’s experience is the subject of Sweet Taste of Liberty: A True Story of Slavery and Restitution in America, which earned author Caleb McDaniel ’06 PhD the 2020 Pulitzer Prize for History. 

McDaniel’s work is “a masterfully researched meditation on reparations based on the remarkable story of a 19th-century woman,” according to the judges. 

McDaniel, Mary Gibbs Jones Professor of the Humanities and chair of the history department at Rice University, was doing household repairs at his home in Houston when a friend called to tell him of the honor. “I was stunned. I was not expecting it all,” he says.  

“I’m also humbled and really gratified that the story of Henrietta Wood would get such major recognition,” he says. “The Pulitzer prizes recognize books about significant aspects of American history. This is a really meaningful way for homage to be paid to her.” 

McDaniel learned about Wood from an 1879 newspaper interview a colleague sent him in the fall of 2014. He saw the story of a Black woman’s successful lawsuit against the man who had enslaved her become more relevant after the racial upheaval following incidents such as Freddie Gray’s death in Baltimore and the fatal shooting of nine in a Charleston church.   

McDaniel’s research for the book required research in archives located in nine states, including Ohio, Kentucky, and Texas, as well as Mississippi, where Wood’s son was born, and Illinois, where her son became a prominent Chicago lawyer. 

He was able to harvest significant information from documents and other sources thanks to “the kinds of skills that the Hopkins history department had equipped me with,” he says. 

“Johns Hopkins was a wonderfully supportive place for me to complete my graduate education,” says McDaniel, noting how welcome he and other graduate students were at weekly seminars hosted by the faculty. 

Having earned his bachelor’s and master’s degrees at Texas A&M, McDaniel says his first foray out of Texas with his spouse Brandy ’04 MA (SOE) required some adjustments. “We know about humidity, growing up in Texas. But we had this romantic idea of snow. We learned quickly there is a lot of hard work shoveling and de-icing,” says McDaniel, whose household was without power for 48 hours after a freak winter storm paralyzed Houston and most of Texas last February. 

McDaniel’s first book, The Problem of Democracy in the Age of Slavery: Garrison Abolitionists and Transatlantic Reform, was published in 2013. Based on his dissertation at Hopkins, it focused on William Lloyd Garrison, who founded and published a prominent anti-slavery newspaper in Boston in 1831. The book earned McDaniel the James H. Broussard First Book Prize from the Society for Historians of the Early American Republic and the Merle Curti Award from the Organization of American Historians.  

McDaniel established a Twitter account, @Every3Minutes, in 2014 that tweets a reminder every three minutes to underscore the fact that 2,000,000 slaves were sold in the United States between 1820 and 1860. 

He explains that his interest in slavery is a natural result of being an historian of 19th-century United States and the outlawed institution’s impact on the period. 

“[History] is an exciting discipline, not one just about recording dates and names,” he says. 

 

The Gullibility Quotient

Stephen Greenspan
Stephen Greenspan
[Photo: Thomas Cooper]

The irony doesn’t escape Stephen Greenspan ’62, an expert on cons and gullibility. In 2009, he lost a good chunk of his retirement savings to one of the world’s best-known con men: the late Bernie Madoff. 

Greenspan was among the 4,800 victims of Madoff, an investment advisor and financier who pled guilty in 2009 to fraud in a $64.8 billion Ponzi scheme. Greenspan learned about his own financial losses two days after getting the first copy of his recently published book, Annals of Gullibility: Why We Are Duped and How to Avoid It

Greenspan didn’t plan on pursuing a career researching cons and gullibility. When he was accepted to Johns Hopkins for his undergraduate studies, he had his mind set on a liberal arts degree. He didn’t even know much about Johns Hopkins at the time.  

A casual comment by his high school guidance counselor brought Greenspan to Baltimore from the Bronx, where he grew up. During his junior year, he went to the counselor to discuss where he should apply to college. It would be their first—and only—meeting. The counselor abruptly dismissed Greenspan’s Ivy League aspirations, randomly flipped through Lovejoy’s College Guide, stopped at “J” and told him, Johns Hopkins was “a really good school, and we only send one or two students a year there.”  

Those first tentative steps began a winding career path from history and political science as an undergraduate, postgraduate work in intellectual disabilities, and research work in Boys Town in Nebraska to his present status as an author on avoiding financial scams. He spent much of his career as a professor of educational psychology at the University of Connecticut. In addition to research articles and Annals of Gullibility, Greenspan has written Anatomy of Foolishness: The Overlooked Problem of Risk-Unawareness, and is working on a new book, Gullibility Politics: Understanding Trump and Trumpism. He is also a leading authority in capital punishment cases involving those with intellectual disabilities.  


Once you enter the world of a skilled con artist, it’s difficult to keep from becoming further ensnared.”

—Stephen Greenspan

So how did Greenspan, too, fall for the Madoff financial scam? He points to four factors that combine to form the perfect storm of gullibility and financial loss: situation, such as witnessing friends, family, or people you trust believing in the scheme; cognition, meaning the ability to understand and evaluate the scheme (Greenspan admits to not being a financial expert); personality, or having a disposition such as impulsivity or a tendency to be too trusting; and emotion, such as feeling relieved that one’s financial future is secure. 

“Once you enter the world of a skilled con artist, it’s difficult to keep from becoming further ensnared,” says Greenspan.   

The best way to avoid being gullible in a financial scheme, says Greenspan, is to look for warning signs and take them seriously. And if someone does become a victim of a con, Greenspan says the most important thing is to learn from it, figure out why it happened, and then make sure it doesn’t happen again. 

“Foolish financial decisions do not always take place in response to a manipulator such as Bernard Madoff,” says Greenspan, “but when they do, many quite intelligent people can be victimized, especially when others they respect and trust have also fallen into the manipulator’s trap and have not yet found out what it really is.” 

Discovery After Discovery

What if pathogenic diseases, like sickle cell and Parkinson’s Disease, could be treated before they even appear? Nicole Gaudelli PhD ’13, Senior Scientist & Program Leader at Beam Therapeutics, tells us that state-of-the art gene editing technology can now alter base pairs in genomic DNA in this TEDMED 2018 Hive Talk.


Nicole Gaudelli PhD ’13 remembers the precise moment she decided to become a scientist. It was fifth grade. Her teacher sent the kids home with the old chestnut of an assignment: What do you want to be when you grow up? Gaudelli’s father, a chemical engineer, asked what her answer might be. “I replied that I wanted to be a doctor because I wanted to help people,” Gaudelli said recently from her home office outside Cambridge, Massachusetts. “He said, ‘Well, doctors diagnose people, but scientists cure people. They’re the ones who make the medicine. Why don’t you want to be a scientist?’”  

The revelation hit her like a lightning bolt. “I never knew I could become a scientist because I never saw women scientists,” she says. The next day, she turned in a picture of a bubbling beaker and a self-portrait, her dark hair sporting a giant pink bow. “I really wanted the teacher to know the scientist was a girl.”  

Last year, Gaudelli’s actual picture appeared in Fortune magazine’s 40 Under 40 list. As the director and head of gene editing technologies at Beam Therapeutics, a biotech firm that recently went public with a market cap of $1.3 billion, she uses the technology that she helped develop to radically change the way genetic diseases are treated.  

Gaudelli never anticipated that she’d end up working in genetics. “I like to joke that I’m a distracted chemist living in a genome editing world,” she says.  

She earned her PhD in chemistry while working in the lab of Craig Townsend, Alsoph H. Corwin Professor of Chemistry, where she focused on natural product chemistry, which looks at substances created through living organisms. She endeavored to answer one of the lab’s longest standing questions: how certain kinds of antibiotics, known as monocyclic beta-lactam, biosynthesize. Understanding that mechanism would allow scientists to reproduce them, but the answer had eluded many before her. For years, Gaudelli worked against the same challenge. “The most important thing I learned at Hopkins is how to persevere in the face of negative results. You learn something with every experiment,” she says.  


The most important thing I learned at Hopkins is how to persevere in the face of negative results. You learn something with every experiment.”

—Nicole Gaudelli

One night, Gaudelli was working in the lab running a test when she received a result she couldn’t believe. She repeated the experiment multiple times to make sure. She fondly remembers what happened next: She took her Maltese puppy on a walk through Charles Village near the Homewood campus, and thought: “I’m the only person in the world right now who knows how monobactams are made.” She went in the next day and put her findings on the desk of Townsend. “He looked at it, smiled, ran his hands through his hair, looked at it again. I teared up.” The results were published in 2015 in a prominent paper in Nature.  

It was during her ensuing post-doctoral work in the Harvard lab of David Liu that Gaudelli made another discovery that would result in a second article in Nature, and become one of the pillars around which Beam Therapeutics was founded. Liu’s lab focuses on genetics, and at the time, a scissor-like gene-editing tool known as CRISPR-Cas9 was capable of cutting genomic DNA, but inefficient at reverting single-letter misspellings, one of the most prevalent causes of human pathogenic disease. Many harrowing genetic diseases, like Parkinson’s, result from a point mutation, or a single-letter misspelling, in our 3.2 billion-base pair DNA sequence encoded by the four nucleobases A, C, G, and T. To fix single-letter, disease-causing mutations efficiently, “a pencil and an eraser” approach would be the optimal solution, Gaudelli explained during a 2018 TEDMED presentation, “not scissors and paste.” One of her colleagues in the lab, Alexis Komor, discovered a way to change C to T. Gaudelli tackled the challenge of creating a molecular tool that could change an adenine base (A) to a guanine base (G). This required creating a new enzyme because there wasn’t a protein with this activity found anywhere in nature.   

Today, she is taking those academic discoveries and turning them into promising therapeutic tools. Gaudelli is currently focusing on sickle cell disease, and while she can’t offer a specific timeline of results owing to her company being publicly traded, she can say that she is “extremely excited about what the future will bring.” Given that Gaudelli is an inventor on numerous base editing patents, you can bet her picture will grace many future publications. 

By the Numbers: COVID-19 Stats

  • Students with a fully in-person or hybrid class: 25%*
  • Zoom minutes: 25.4 million** 
  • Total JHU student COVID-19 tests conducted: 127,000*** 
  • Faculty doing covid research: 18+ 
  • Cardboard cutout fans at lacrosse and baseball games: 281*** 

    *Based on a March survey  
    **First three months of 2021 
    ***As of mid-April 

Watch this short video of recent scenes from around campus.

https://youtu.be/QDBa8RcJyRA

Major Infatuation: Physics and Astronomy

Tell us why you love your major.

“I love being able to study what feels truly fundamental to me, be it the tiniest particles, the biggest stars, or even the nature of space and time.” 

Jake Hassan ’21 

“Studying physics gives me a unifying perspective of the world around me, from the way milk diffuses in my teacup to how stars move across the night sky. The blessing and curse of physics is that there are always more questions than answers.” 

Vedant Chandra ’21 

“I love physics because it is a beautiful description of our world, and I love the JHU physics department because it encourages this love through exciting research.” 

Zubia Hasan ’21 

“I love physics and astronomy because I have always been fascinated by maps and what they can tell us. As an experimental cosmologist, I am involved directly in building instruments to map the sky and help us better understand the earliest moments of our universe.” 

Ben Keller ’21

 

Sports Bits

Women’s Basketball 

Head coach  Katherine Bixby  announced that Kayla Robbins will join the coaching staff. Robbins arrives from four seasons as a member of the Michigan women’s basketball team, where she contributed 610 points and 364 rebounds over her career. 

Men’s Football 

Jay Anderson was named defensive coordinator. Anderson was most recently the associate head coach and defensive coordinator at Notre Dame College of Ohio. Before that, he spent six seasons as head coach at Oberlin College. 

Women’s Field Hockey 

The Blue Jays placed a national-best 28 student-athletes on the 2020 National Field Hockey Coaches Association Division III National Academic Squad, boasted six Scholars of Distinction, and posted the fourth-best team GPA. 

Men’s Tennis 

Head coach  Chuck Willenborg will step down at the end of the 2021 season after 17 seasons at the helm. Willenborg came to Homewood in 2005 to coach both the men’s and women’s teams, and guided Hopkins to double-digit win seasons in every year except for the COVID-shortened 2020 season. 

Women’s Tennis 

Head coach  Dave Woodring will step down at the end of the 2021 season after 17 seasons with the Blue Jays, including the last 11 as head coach. His teams have won 169 matches, three ITA National Indoor Championships, and nine Centennial Conference titles, and made nine NCAA Tournament appearances. 

Men’s Baseball 

The Blue Jays were picked atop the Centennial Conference preseason poll, with seven first-place votes to earn 49 total points in the poll. The team went 12-3 in the truncated 2020 season.  

Five Questions: Jessie Martin

Jessie Martin in a garden on campus
Jessie Martin [Photo: Will Kirk]

Jessie Martin,assistant dean for academic advising, came to the position in 2018 after three years as director of academic advising at Johns Hopkins’ Carey Business School. Before Hopkins, she served as an advisor in the community college system, where she still teaches courses in human development across the life span.

What is the primary mission of academic advising?

We start working with students before they arrive on campus and throughout their first year. We talk about course registration, academic interests, major and minor choices, adjustment to college life, and cocurricular experiences. When students have problems in the classroom, we do proactive outreach. We ensure students are meeting benchmarks and progressing appropriately.

What else falls under your umbrella?

We offer a suite of academic supports. We have both group and individual tutoring. PILOT, a peer-led learning group, uses group peer learning to practice concepts. During the pandemic, we started self-directed study groups where we matchmake for students who want to study in groups. The Study Consulting Program pairs upperclassmen with lowerclassmen to improve learning strategies. Arrive and Thrive courses are a one-credit, first-year seminar for building academic skills and accessing resources. 

How does your support evolve throughout a student’s career?

When students declare a major they are transitioned to a faculty advisor, but we’re still there. If they’re not performing well, we provide an academic coaching service. If they have questions outside their discipline, like about policy or academic strategy, sometimes they continue meeting with us.

How do you collaborate with other offices?

We refer students to resources like the Life Design Lab, Student Outreach and Support, contacts in their academic departments, and the Office of Undergraduate Research based on their interests and goals.

What’s your newest project?

When a student’s family members didn’t go to college or a student is facing financial challenges, we connect them to a success coach advisor who works with them all four years. The goal is t go beyond academics; the advisor steps in as the person with experience to guide them through all the unfamiliar steps to maximize opportunities, like summer internships.

Field Notes: Stock Answers

Johnny Saldana
Johnny Saldana [Photo: Will Kirk]

The stock market can seem a fickle and enigmatic arena operating under its own rules and growing increasingly volatile and unpredictable with each passing year. This is an age where a single presidential tweet can roil Wall Street and stocks have hit record highs amid a pandemic that has left millions of Americans out of work. Just recently, a plucky group of amateur investors grabbed headlines after rallying together online to explode the stock value of moribund video game retailer GameStop—giving financial black eyes to some established hedge funds.  

The field of quantitative finance emerged in the 1970s as a form of applied mathematics focused on creating models to provide a level of market predictability. Junior Johnny Saldana, double majoring in economics and computer science, is using a Woodrow Wilson Fellowship to continue that work. “I am interested in finding and analyzing financial trends using large datasets and computational tools,” he says. 

When things go haywire in the market and analysts are caught flat-footed, Saldana feels it’s because the risk models being used don’t account for “black swan events” and other anomalies. “You can’t really model risk in financial markets with the normal tools that most people would use when looking at data because these markets just don’t respond the same way,” he says. “One area of my research I explored was trying to use fractals to better model stock movements.” 

When the fractal approach proved less than fruitful, he turned his focus to commodity markets. Saldana realized that crude oil was not a good place to start: It had too many variables pushing and pulling its price. Instead, he began following news about lithium, which is mined in limited geographic areas and encompasses a much smaller universe of stocks.  

“Every couple weeks, there might be news of a lithium deposit discovered in some rural area,” he says. “I can track those events and look at how they impacted share prices across multiple lithium companies. If I can achieve some reasonable level of analysis for this very small market, I can bring the tools and research up to a more complicated scale.” 

The quest goes on, and he’s not alone. In 2018 he helped found the Quantitative Finance Club at Johns Hopkins. “When exploring new ideas, it helps to have a community of people with the same interest,” Saldana says. “A lot of the research ideas I’ve pursued have come from talking with members.” 

Field Notes: Poetry in Motion

Sarah Elbasheer
Sarah Elbasheer [Photo: Leena Elbasheer]

Junior Sarah Elbasheer is a medicine, science, and humanities major drawn to exploring the history of science—especially going beyond the conventional narratives sometimes encountered in the field. “There is a tendency to skip over other cultures and draw a straight line between ancient Greece and the Renaissance in Europe,” she says. 

This approach slights Asian and Middle Eastern contributions to science and medicine, she notes, and also instances where these worlds collided, such as in the Tānsūqnāma, a 1313 Persian (modern-day Iranian) manuscript, which translates as The Treasure Book of the Ilkhans on the Chinese Arts and Sciences. Originally in four volumes, only one survives and it is secured in an Istanbul library. Working from scans, Elbasheer is focusing on the half of the volume that contains Persian translations of Chinese “pulse medicine,” a diagnostic system interpreting the strength and rhythms of the pulse. (Elbasheer notes that you can still find practitioners of this traditional medicine in China and India.)  

Pulse medicine is composed in rhyme. It’s medical poetry. “It is written that way to help medical students to remember the diagnostic techniques,” Elbasheer explains.  

This mnemonic scheme was part of the original Chinese text. But if anything is bound to get lost in the translation between entirely different languages, it’s rhyme. For instance, in a Latin translation of these same Chinese poetic pulse diagnostics, all the medical information is conveyed in the new language, but the rhymes from the original Chinese are gone.  

Persian polymath Rashid al-Din, credited with compiling the Persian version, took a different approach. “He takes advantage of a shared tradition in both China and Persia for rhymes used in medical education,” Elbasheer says. “What we see is this attempt to preserve the sound of the poetic performance, creating an entirely new linguistic system to preserve the sound of the verses. So, basically, it is trying to connect the tradition in Persia about the emphasis and importance of oral performance and didactic poetry to the effort of preserving the verses.” 

Elbasheer’s ongoing analysis of this ancient bilingual, bicultural work will likely be the subject of her senior thesis. She finds it to be a fascinating example of medical concepts moving west along the Silk Road coupled with an intricate linguistic solution to preserving both their sound and science for a new culture. With apologies to Rashid al-Din, she admires the Persian version after the conversion. 

Field Notes: Cultured Cancer Killers


Wesley Ravich remembers feeling helpless after a childhood classmate developed leukemia and began a difficult course of treatment. He channeled those emotions into a life calling: “I really wanted to work in pediatric oncology,” Ravich says. “That was my passion.” 

The junior biology major has done just that since arriving at Hopkins. A Woodrow Wilson Fellowship initially funded his work in the lab of Challice Bonifant, his mentor and an assistant professor at Johns Hopkins School of Medicine. It was supplemented last summer by a Provost’s Undergraduate Research Award and is now funded by the Alex’s Lemonade Stand Foundation for Childhood Cancer. The Bonifant lab works largely to study two prominent forms of pediatric cancer: acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Traditional treatments for these cancers include chemotherapies and stem cell transplants, which often have debilitating side effects. And even with these intensive treatments, a percentage of patients do not respond while others relapse. The Bonifant lab explores the burgeoning field of cellular immunotherapy, which is poised to revolutionize leukemia therapy with the potential for more effective, less debilitating cancer treatments. 

The approach uses the patient’s own immune cells, which are removed, genetically modified to target specific cancers, and returned to patients to do their work. The main type of immune-system cell Ravich works with are the natural killer (NK) cells of the innate immune system. Before the modified “killers” are let loose on a patient’s cancer, they need to be primed for the fight. They need to thrive once administered, the term for which is “cell persistence.”  

“With NK cells, you need to ensure that they’re activated and able to proliferate when they’re given to patients,” Ravich says. “To activate them, you first expose them to certain cancer ‘feeder’ cells that are similar to the cancer cells you’re trying to target. And you can engineer these feeder cancer cells so that they express certain signals that will serve to further activate the NK cells. I was studying the best way to optimize the activation of NK cells targeting AML.” 

He uses the past tense because, as of this writing, COVID-19 has shut down his in-person lab work. Fortunately, he was able to find a new way to channel his cancer-fighting energies. He has worked to explore a commercially available cellular immunotherapy approved for use in pediatric ALL patients, and in collaboration with a team at the St. Jude Children’s Research Hospital in Memphis, Tennessee, Ravich compiled available clinical data for a study analyzing cellular persistence.  

“We looked at the importance of persistence and other factors that should be explored, moving forward, that could hopefully lead to better outcomes,” Ravich says. “We’re really just scratching the surface of what this field has to offer.” 


Update
Ravich is first author of a paper describing his cancer immunotherapy treatment research published in the Journal of Transplantation and Cellular Therapy on December 4, 2021.

Field Notes: Privacy or Prevention?

Lauren Mayten portrait shot
Lauren Maytin [Photo: Will Kirk]

The chances of becoming seriously ill or dying from COVID-19 increase with age, with senior citizens at the greatest risk. Young adults, though not immune to the disease’s worst, are more likely to have mild cases—sometimes with no symptoms at all. What young people are at risk of doing is spreading COVID-19, which makes the importance of contact tracing—the ability to quickly and thoroughly identify and reach out to people an infected individual encountered—all the more important. Fortunately, most young people have a powerful tool to help with this in their pockets: a smartphone.  

But how willing are they to engage in phone-based “digital contact tracing” to curb the pandemic? To find out, sophomore Lauren Maytin helped develop a survey given to more than 500 people ages 18 to 24 last summer. She was lead author for the resulting article, “Attitudes and Perceptions Toward COVID-19 Digital Surveillance: Survey of Young Adults in the United States,” published in the January issue of Journal of Medical Internet Research. The survey was a COVID-19-forced pivot from what was supposed to have been an in-person internship at a health care consultancy. Instead, Maytin worked remotely with the consultancy on this urgent topic. 

“I was thrilled to be able to do something to help,” says the behavioral biology major. “There wasn’t much information available about this demographic at a time when everyone was trying to figure out if we were going back to campus, or kids back to school.” 

And the results surprised her. While some three-quarters of the demographically diverse young respondents (compiled using the online survey company SurveyMonkey) believed COVID-19 was a public health crisis, there was significant reluctance to participate in digital contact tracing. Fewer than half indicated a willingness to “actively” participate (meaning they’d be willing to manually enter data into their phones, such as any symptoms they were experiencing). Barely a third were willing to “passively” participate—allowing their phone to track their movements. Such lackluster interest may highlight the need for more education about the importance of contact tracing. 

“I was surprised because there’s such widespread use of social media and websites and apps that track your activity anyway, like Snapchat or any of the map and navigation apps,” Maytin says. “If you can track your friends in a social setting, that’s fine. But if someone’s asking you to be tracked for public health purposes, suddenly it’s an invasion of privacy?”