Five Questions with Misti McKeehen at Center for Social Concern

Misti  McKeehen  has been  executive director of the Johns Hopkins Center for Social Concern (CSC)  since  2018.  The CSC offers programming  in civic engagement  that combines education, action, and reflection.   


What is a typical day like for you?  

There isn’t a typical day. Most of my days include planning with my staff;  student engagement, whether that be a coaching meeting or speaking to one of our programs  or  interacting with some of our interns; and  engagement  with Baltimore organizations  that are working  with our students in a community service capacity.   

Why is community engagement important for undergrads?  

Everyone is going to be part of a community,  no matter where that community is in the world.  I encourage students to think about  what experiences shaped who you are,  and how can you use those passions to find something that might be related to your major or your future profession— but also might not?  Civic engagement  allows you to be a good neighbor to people who are not just living next to you and  who  you’re working with;  thinking about your role in the larger context is so important.   

What is a key message you hope to give students?  

Listen first. Always listen to the community;  the community knows what they need. The organizations know what has been done  and what will be impactful.  So never assume you have the answers. Even if you have a great idea, it might not be the answer for the community.   

What role  does community engagement play in your own life?   

I spent  my early  career in civic engagement and experiential leadership  at a nonprofit,  looking at  how the sectors intersect  around  community development.  I really enjoy the opportunity to identify how to help build capacity around a city’s  systems and services.  Here, I feel very fortunate to have been welcomed  here in Baltimore  and  to  have joined this community that is passionate and talented and has so many great organizations.  I see the development of our students as one  win  of doing this work,  while also helping an organization move toward  its mission.   

What is your  favorite part of your job?  

It’s the moment where students find their  passions,  when they have  an  experience with  a  community partner  where  they’re connecting with one another and excited about the work  that’s being done.  I really enjoy helping students navigate what it means to be part of a community and to understand how that will play a role in their life moving forward.     

Fall 2021 Sports News

Women’s Volleyball 

The Blue Jays took home their fifth straight Centennial Conference Tournament title after finishing their 2021 regular season with a perfect 27-0. Their win streak stands at 64 as they extend the Division III record and push toward moving up to second all-time throughout all divisions.

Men’s Soccer 

The Blue Jays jumped 14 spots in a September United Soccer Coaches Poll to number eight in the nation. The team also jumped to the top spot in the regional rankings. At 5-0-2 overall, Hopkins was off to its best start since the 2017 season. 

Women’s Soccer 

With a 4-0-1 start in September, Hopkins moved up to number two in the third edition of the 2021 United Soccer Coaches Poll. The ranking is tied for the highest in program history, matching 2013.  

Football 

The team carried a pair of top-15 national rankings into its bye week as the Blue Jays were ranked 13th in the American Football Coaches Association (AFCA) Poll and 15th in the D3football.com Poll. Hopkins was 5-0 overall and 4-0 in the Centennial Conference after the first half of the season. 

Women’s Tennis 

Krieger School seniors Jessica Liang and Sophie Saland competed at the 2021 Loyola Invitational in October. The invitational was run as a “Fed Cup” style tournament, with teammates competing together against other pairs in a doubles and two singles matches. Liang and Saland competed against an all Division I field. 

Men’s Cross Country 

The number eight Blue Jays took second place at the John “Paddy” Doyle Meet of Champions in September. Hopkins placed five runners in the top 25. 

Fall 2021 Krieger Alumni to Watch

  • Samuel Cheney ’19 (MFA) received a 2021 Pushcart Prize for his poem “On the Footage of Monet Painting.”
  • Stuart W. Davidson ’79, partner at Willig, Williams & Davidson, was named among the 2021 Pennsylvania Super Lawyers for the 18th year in a row. Pennsylvania Super Lawyers is a peerreviewed, independently researched rating service of outstanding lawyers who have been identified as attaining a high degree of professional achievement.
  • Eat Wheaties!, a movie based on The Locklear Letters, a novel by Michael Kun ’84, won the Best Comedy award at the 2020 San Diego International Film Festival and the Humor award at the 2020 Heartland Film Festival.
  • Emmett F. McGee ’81 was recognized in the 2021 edition of Chambers USA: America’s Leading Lawyers for Business, a prestigious annual guide ranking the leading law firms in the U.S. McGee is a principal in the Baltimore office of Jackson Lewis P.C.
  • Mark Monmonier ’64, Distinguished Professor Emeritus of Geography and the Environment at Syracuse University, received the Chancellor’s Citation for Excellence Lifetime Achievement Award in recognition of extraordinary contributions to the undergraduate experience and research excellence, fostering of innovation, and support for student veterans.
  • Michael A. Moskowitz ’64 is part of an international team that received the Brain Prize 2021, a $1.5 million award for groundbreaking work on the causes and treatment of migraine.
  • Divorce, Simply Stated: How to Achieve More, Worry Less and Save Money in Your Divorce, by Laurence Sarezky ’71, was ranked Best Family Law Book of All Time by Book Authority.
  • Elena Walsh ’09, college access specialist and teacher at Benjamin Franklin High School at Masonville Cove in Baltimore, was one of 12 recipients of the 2021 Counselors That Change Lives Awards from the nonprofit Colleges That Change Lives.

Curriculum Vitae: Alumnus Monica Schoch-Spana

Medical Anthropologist 

Monica Schoch-Spana
Monica Schoch-Spana

Education  

  • 1986 Bachelor’s degree, cultural anthropology, Bryn Mawr College  
  • 1992 Master’s degree, cultural anthropology, Johns Hopkins University 
  • 1998 Doctoral degree, cultural anthropology, Johns Hopkins University 

Notable 

  • During COVID-19 response, collaborated in producing guidance to top executives in the nation on reopening principles, mental health challenges of the pandemic, and school reopening decisions 
  • Published more than 15 COVID-19-related articles during the past 18 months to help guide communities during the pandemic 

National advisory roles 

  • The Homeland Security Subcommittee of the Board of Scientific Counselors for the U.S. Environmental Protection Agency 
  • The Resilient America Roundtable of the National Academies of Sciences, Engineering, and Medicine (NASEM) 
  • NASEM Committee on Community Engagement in Southeast Texas: Pilot Project to Enhance Community Capacity and Resilience to Floods 

In Her Own Words

There will be certain messages that resonate really well in Baltimore City among local Black communities that may not resonate well with rural frontier Hispanics in southeastern Idaho. So we have to have to those hyperlocal perspectives.”

The New York Times, Dec. 2020, on encouraging people to get vaccinated.

Humans are not as simple as viruses. They have personal histories, opinions, wants, and needs. They are embedded within social networks that have their own unique configurations of worldviews, and they are members of cultures that offer particular interpretations of the body, disease, and treatment—which do not always conform to the perspectives or interests of biomedicine and public health.” 

Sapiens Anthropology Magazine, Jan. 2021

Community engagement is hard, time-consuming work that requires an adequate number of personnel and a robust operating budget, and we need to get dollars into these type of line items.”

Phoenix New Times, Feb. 2021

Hopkins Film and Media, Then and Now

Then 

Twenty-four years after this photo appeared in Johns Hopkins’ 1971 Hullaballoo yearbook, the Film and Media Studies program was launched in response to swelling student interest in film and media. In the program’s first five years, the number of majors grew from five students to 27. Do you know who this student is? Please contact us at [email protected]

Now 

Today, the Film and Media Studies program (FMS) typically hosts about 30 majors and 15 minors, and the largest number of double majors among the humanities. The program combines an industry education with a rigorous curriculum to foster critical understanding and historical knowledge of film and media, as in this 2019 shot of Amanda Pak ‘22 in an Introduction to Film Production course. Most of the program’s graduates plan a career in some aspect of film or media. 

Creating Safer Roads through Policy

Natalie Draisin
Natalie Draisin

When Natalie Draisin ’10, MPH/MBA ’15, was an undergraduate at the Krieger School, her sorority sister was killed by a drunk driver who had  several  DUI infractions on his record.  

“[It] was an unimaginable tragedy,”  Draisin  says. “To me, her tragedy was a human rights violation. Everyone should have the right to cross the street without worrying about whether they are going to get to the other side.”  

Draisin’s Alpha Phi sorority sisters and the campus community mobilized to work with the Baltimore Department of Transportation and Mothers  Against  Drunk Driving to redesign Charles Street to help prevent future incidents, she recalls.  

That experience helped put her on a career path that led to her current position as director of  the  North American  Office  and United Nations  Representative  for the London-based FIA (Federation  Internationale  de  l’Automobile)  Foundation. The group’s mission: to reduce  the 1.35 million  deaths  and more than 20 million injuries  annually  on the world’s roads.  

“The public health community avoids using the term ‘accident.’ That implies tragedies could not have been prevented. We use ‘crash’ because we know serious injuries and fatalities are preventable and therefore unacceptable,” she says of her work with the foundation, which was founded in 2001 with a $300 million donation from the FIA, a nonprofit  that includes motoring organizations worldwide and is the governing body of world motor sport.   

Global Road Safety

Draisin  learned of the FIA Foundation  while  interning with the World Health Organization  and joined the group in 2015. Prior to that, while  a  graduate student  at the Bloomberg School of Public Health, she  worked with the  National Transportation Safety Board.  Before returning to graduate school, she worked in  community health in Kenya and  was  a  leadership  fellow with the Pew Charitable  Trusts.  

Though her office is based in Washington, D.C., she was on the road often in her first years with the organization, with destinations as diverse as Ghana, Senegal, Denmark, France, Sweden, Ecuador,  Colombia,  and Brazil.  Since the pandemic,  though,  her travel  time and commute has  dropped to zero.  

“The pandemic has opened up a window of opportunity where the political will and public desire for safe streets align. People are understanding the benefits of moving away from cars,” she says,  citing  residents’  increased appreciation for closing city streets to allow more foot traffic.  


“Today, one of my major focuses is to get the United States re-engaged in global road safety. It significantly dropped off in the last four years.

— Natalie Draisin

Incorporating  life-saving strategies  in  the  infrastructure  bill  currently before  Congress  is high on  Draisin’s  priority list.  Among the recommendations issued:  allocate federal funding to improve equity in road transportation; incorporate protected bicycle lanes and roundabouts; reduce speeds to a safe level; and introduce alcohol impairment detection technology in new vehicles.  

She says  the U.S. Centers for Disease Control  and Prevention and  the  National Highway  Traffic Safety Administration play a role in ensuring  more children have safe routes to school in the United States. “What we do in this country has implications around the world,”  Draisin  says.  “I’m excited that we’re at a turning point to address road safety as never before.”  

The elementary school her son, now 2, would attend is only a five-minute walk from her Northern Virginia home, she says. But  as is true in  much of suburban America, there are  no  sidewalks or crosswalks on the route. “This is something that has to change,” she says.   

Sensing Illusions with More than Vision

Is it possible to perceive the impossible? The answer is a resounding “yes!” from Isabel Won, a psychology and cognitive science double major who graduated in May. She spent most of her years at Hopkins as a research assistant in the Perception and Mind Laboratory led by psychological and brain sciences Assistant Professor Chaz Firestone.  

Isabel Won

Seeing the impossible is pretty common. Artists are adept at creating optical illusions by manipulating shading and perspective to create 2D depictions of impossible 3D objects or places—think famed Dutch illustrator M.C. Escher and his staircases doubling back on themselves in endless loops. But Won wondered if other senses could perceive the impossible. “There weren’t really many studies on illusions that aren’t primarily visual,” she says. 

One classic example that is widely known involves a size-weight illusion wherein people are presented with two objects of different size but identical weight. When asked to lift both objects, a majority of people perceive that the smaller object is heavier than the larger one.

Weight and Illusion

Won took this concept into the impossible zone with an experiment involving three identically sized plastic boxes. Two boxes are empty and weigh the same, and one has a metal weight mounted within it. Participants are asked to lift the three boxes together and then the weighted box by itself.

The kicker? Some 90 percent of the participants she tested perceived the single box as being heavier than all three together.  

“I tested it out with students on campus—just sitting in front of different buildings and calling people over to participate,” Won says.

Which feels heavier? The single box or three stacked boxes? 90% of the participants in Won’s experiment perceived the single box as being heavier than all three together even though their weight is the same.

It was a ton of fun and everybody was extremely intrigued and fascinated by how convincing this illusion was.”

— Isabel Won

A skeptical Won tried the experiment herself and also experienced the illogical sensation. “Even knowing that it was an illusion and it was impossible, I still felt it strongly every single time I experienced the experiment myself,” she says. 

Won says the sensation violates a traditional thought process known as Bayesian reasoning. In essence, it says that when our minds confront ambiguous information, we are attracted toward what we already know. In this case, our brains tell us that an object lifted together with two others is certainly going to weigh more than the single object by itself.  

The results of her weighty project were published in the July issue of the cognitive science journal Open Mind. “My takeaway is that our mind is able to process super impossible illusions in ways that we didn’t really expect previously,” she says.

Setting a Path for Black Women in Physics

Jami Valentine Miller
Jami Valentine Miller, PhD ’06

Among a sea of physicists, a Black woman tends to stand out, says Jami Valentine Miller, PhD ’06. In the past, when she’s attended large conferences in her field, “it’s not hard, out of thousands of people, to spot the one person who’s like you,” she says. “And then it’s like, ‘Well, let me go over and introduce myself.’” 

Many of the women Miller has met over the years are now officially honored on her website, African American Women in Physics, AAWIP.com. Today the site lists more than 150 Black women in the U.S. who have earned their doctorates in physics, are current graduate students in physics, or have worked in the field. 

The group grows steadily each year, says Miller, who started the site in 2005 as she was working toward her own PhD in physics at the Krieger School. 

“I began collecting a list of all the different Black women I was meeting at these conferences, and posted it on my Hopkins website. And I’d ask around trying to find others,” she recalls. “At the time, most departments didn’t keep track of this kind of demographic information.” 


We have women working on planetary structures at NASA, women doing geochemistry at Chevron, women doing intellectual property law, quantum physics, cultural astronomy…”

— Jami Valentine Miller

College and Career

At some point, Miller realized hers was the only name from Johns Hopkins. When she completed her doctorate in physics, she earned the distinction as the first Black woman in the university’s history to do so. 

Miller ended up pursuing a career as a patent examiner at the U.S. Patent and Trademark Office, where she works on applications for semiconductor and spintronic memory devices, which include devices and features for Samsung and Apple products. 

She teleworks from Orlando, Florida, where she lives with her husband, whom she first met during her undergraduate studies at Florida A&M University and then reunited with years later. She earned her master’s degree in physics at Brown University before moving to Johns Hopkins for her PhD, where she studied under  Professor Chia-Ling Chien

Though her work now leans more toward electrical engineering than physics, Miller says: “I’m lucky and it turned out to be the perfect job for me. I know the work I do is important, and I see it play out in products that I use and see in the news.” 

Trailblazers in Physics

Other women on AAWIP have followed similarly varied career trajectories—in many cases diverging from the traditional academic path where the goal is a tenured professorship. “We have women working on planetary structures at NASA, women doing geochemistry at Chevron, women doing intellectual property law, quantum physics, cultural astronomy…” Miller says. “One manages a jazz band.” 

The AAWIP list now includes one other Hopkins alum:  Lynnae C. Quick, ’11 MA, ’13 PhD, who was the second African American woman at Hopkins to earn her doctorate in Earth and planetary sciences and is now a planetary geophysicist at NASA. 

The site also honors past trailblazers, including Willie Hobbs Moore, the first-ever African American woman to earn a PhD in physics; NASA scientist Katherine Johnson (depicted in the movie Hidden Figures); and Carolyn Beatrice Parker, who contributed to plutonium research for the Manhattan Project. 

It’s a small but distinguished list of women—sitting at the intersection of two underrepresented groups in a field dominated by white males. Between 1998 and 2018, consistently less than 25% of physics degrees in the U.S. have gone to women, according to the American Physical Society, while underrepresented racial and ethnic groups have accounted for consistently less than 10% of physics degrees during that time. 

AAWIP exists not only as a platform for celebrating these women, but also for building mentorships and networking opportunities, Miller says. 

“For those who want to hire more diverse candidates,” she says, “we are out here. We exist.”

Sustainable Solutions Through Biodesign

At the first annual summit of the Biodesign Challenge (BDC) in New York in June 2016, a group of students from the Fashion Institute of Technology presented swatches of fabric made of a yarn-like material that they had synthesized from kelp.  

“And the judges chose them as the winner,” says Daniel Grushkin ’99, founder and executive director of the BDC. “The wonderful thing is that their material is sustainably sourced, and of course it biodegrades, so theoretically, when you’re done with your knitwear, you can add it to the compost to feed your plants,” he says.  

After the competition, the students went on to form AlgiKnit, a company that produces eco-conscious, renewable yarns and employs 16 people in Brooklyn.

Above, prototype of AlgiKnit fibers synthesized 
from kelp.

Now in its seventh year, the Biodesign Challenge is an international competition for high school and university students. The competition brings together scientists, artists, and designers to imagine and create new applications of biotechnology. Students work in teams on projects throughout the school year while receiving guidance from local mentors identified by BDC. Then, in June, the finalist teams gather at a summit where they present their projects to a panel of judges. The panel includes scientists, artists, designers, entrepreneurs, and others—and compete for prizes, including the grand trophy: the “Glass Microbe.” 


Daniel Grushkin
 

It became clear to me that if we’re going to see really thoughtful applications of biotechnology in the world, it was going to come through collaborations like these.”

—Daniel Grushkin

Genspace

Before starting BDC, in 2009 Grushkin co-founded Genspace, a community laboratory also located in Brooklyn. Initially billed as a “hacker space for biology,” Genspace offers members of the general public the opportunity to pursue their own biotechnology projects independently. The members include those from nontraditional and underrepresented backgrounds.

Grushkin has long been interested in exploring connections between the worlds of art and science. As an undergraduate at Hopkins, he majored in English while also taking a number of math and physics classes. After graduating, he worked as a reporter for several years and found himself drawn to writing about science.  

“I started to get interested in the culture of science, and in how science becomes business, and then I got interested in how science really becomes culture and art,” he says. 

Reporter to Founder

In 2008, he began writing about the emerging field of synthetic biology. He heard about a group of scientists in New York who were interested in bringing the tools of the laboratory into their homes for a “do-it-yourself” version of bioengineering.  

That appealed to me—it both raised hackles and seemed concerning [from a biosecurity perspective], and at the same time, it seemed really exciting,” he says. 

As a reporter, he attended the first organizational meeting of these scientists at a diner. At the end of the meeting he found himself offering his apartment as the location for the next meeting. “And so I went very quickly from being a reporter to one of the founders of what ended up becoming Genspace,” he says.  

As Genspace was evolving, Grushkin started to notice that not only scientists were showing up at the community laboratory. Also artists and designers, who would sometimes collaborate with the scientists in meaningful ways.  

“It became clear to me that if we’re going to see really thoughtful applications of biotechnology in the world, it was going to come through collaborations like these,” he says.   

Biodesign Challenge

So, in 2015, Grushkin launched the Biodesign Challenge. The program is geared toward young people that would encourage this kind of cross-disciplinary discussion and interaction. 

The program started at nine U.S. high schools in 2015-16. It has since grown to include 51 high schools and universities in 20 countries. BDC has also found a number of sponsors, including biotech firms like Ginkgo Bioworks and Twist Bioscience. But also Stella McCartney, the fashion brand, and Barilla, the pasta company. 

Looking toward the future, Grushkin believes biodesign will eventually become a standard design discipline at art and design schools. He thinks that ideas coming out of biodesign will increasingly be adopted by companies looking for sustainable solutions. 

“I think that the decisions about how technology gets distributed and rolled into the world—how it emerges into the world—don’t belong only in the hands of entrepreneurs and/or scientists,” he says. “There needs to be a community conversation that involves people from different backgrounds who are knowledgeable and can speak the language of the science. What’s important is that we’re bringing those other voices into the conversation.”

Creating Tools for Reading with Dyslexia


Ava Powell
Ava Powell [Photo: Will Kirk]


Dyslexia is the most common of all neurocognitive disorders, causing as many as one in five people to have difficulties in learning to read or interpreting letters and words. Junior Ava Powell is well aware of the disorder’s complexity.

“It’s really like a bunch of different disorders wearing a trench coat,” the cognitive science and Writing Seminars major says. “Like other neurological divergences, such as autism and ADHD, dyslexia is on a spectrum. It can be hard to define because it can be so individualized.” 

Powell remembers that her younger brother was in third grade before his school realized he was only reading at a kindergarten level and tested him for dyslexia. “That opened my eyes to the  obvious need for more support for students with  dyslexia,” she says. Empowered by a Woodrow Wilson Fellowship, she is developing a tool to help: a specialized and customizable e-book system to function as a reading coach. She hopes it will allow people with dyslexia to become “agents of their learning,” and maximize their reading potential.  

E-book System

The web-based e-book system will operate at many levels. At its most basic, users can customize the font, line spacing, and other aspects of the layout to a level that visually works best for them. “You could also click on any word and it can read the word to them,” Powell says. “I also want to have it so that they could break words down into syllables, and have the system sound out each syllable.”



She’d also like the system to explain a word’s morphology. That could just be a dictionary definition or also involve explaining any prefixes and suffixes. Powell will do her own coding and is learning HTML now while brushing up on Python, a programming language she has some familiarity with. The goal is to have a working prototype by the start of her senior year.  

While Wilson Fellowships are usually guided by a student’s major, Powell says her e-book idea helped her choose hers. “I already knew that I liked writing,” she says. “And I was like, hey, what major is related to this project? That’s how I discovered cognitive science.” 

Powell hasn’t established how she will formally test her system. She might have her brother play around with it in an unofficial capacity. “I also thought about giving access to the software to an actual classroom teacher and having them give me feedback on how their kids like it,” Powell says. If it comes together as planned, her e-book should make a teacher’s life—and those of students with dyslexia—a little easier. 

Exploring How Muscles Regenerate

Colt Crain working in Professor Chen-Ming Fan’s lab at the Carnegie Institution. [Photos: Will Kirk]

The mechanisms allowing muscles to regenerate and repair themselves remain a mystery of cellular biology. Gaining a greater understanding of this process has many implications. Implications include potential treatments for diseases such as muscular dystrophy, a genetic condition that causes muscle degeneration.  

Junior molecular and cellular biology major Colt Crain has been exploring this process since freshman year when he joined the lab of adjunct biology Professor Chen-Ming Fan in the Carnegie Institution for Science’s Department of Embryology. Crain is currently the only undergraduate member of the lab, which brings benefits undergrads in larger labs might not enjoy.

“It gives me more opportunities to work directly with Dr. Fan,” Crain says. “He can more easily devote time to teaching me and helping me with experiment protocols, and I also have a little more autonomy in what I do.” 

What he has been doing lately is an experiment to determine if a specific protein is necessary for muscular regeneration. Stem cell surface proteins known as integrins provide a mechanism for such undifferentiated cells to interact with their surroundings. That includes, it is thought, to engage in the biochemical signaling that prompts such cells to make more cells and then to differentiate into new muscles.

Muscle Differentiation

The lab previously discovered that the presence of the protein β1-integrin is necessary to make more cells at the first step. Crain has been looking at whether another integrin, β3-integrin, plays a similar role in muscle differentiation in the second step of regeneration. 

His work involves three types of mice. Some have the β3-integrin knocked out by chemical injection. Others are genetically modified to be born without the β3-integrin in the muscle. Along with control mice, those mice are subjected to localized injury via the injection of a small amount of toxin derived from snake venom. Ultimately, the injured areas are examined under a microscope. 

“If we expect to see any difference, it would be that in the mice lacking the β3-integrin, their muscle fibers won’t regenerate—the stem cells that muscle fibers come from won’t fuse and make bigger and newer muscle fibers,” Colt says. “You’re basically just left with teeny tiny fibers, which leads to muscle degeneration.” 

The project is nearing completion and he hopes to publish soon. So far it appears that β3-integrin is not necessary for muscle repair. “We’re basically seeing normal muscle in all of the mice,” he says.  

Though sometimes he feels “thrown into the deep end” at the lab, Crain’s hands-on experiences provide an invaluable glimpse into the world of bench research. It all contributes to his ultimate goal: a PhD followed by a career in vaccine development. 

Fighting Cancer One Cell at a Time

Undergraduate researchers should always be motivated by the accomplishments of their mentoring professors and lab leaders. But when it comes to setting the aspirational bar at the highest notch, it’s hard to top School of Medicine Professor Gregg Semenza. In 2019, the year senior biophysics major Chelsey Chen began working in Semenza’s lab, he and colleagues from Harvard and Oxford universities won the Nobel Prize in physiology or medicine. 

Chelsey Chen
Chelsey Chen in front of the Undergraduate Teaching Laboratory on the Homewood Campus.
[Photo: Will Kirk]

“He passed it around the lab and let me let me hold it, which was really amazing,” Chen says of the gold medal that is part of the award. And medicine and science are the real winners. Semenza’s breakthrough discovery on how cells respond to low oxygen levels offers enormous potential for developing treatments for a variety of diseases, including cancer. 

Semenza discovered a protein called hypoxia-inducible factor 1 (HIF-1). The protein turns genes on and off in cells in response to low oxygen levels. Much of Semenza’s lab work now revolves around understanding how HIF-1 might promote breast cancer metastasis. 

Cancerous tumor cells can divide very quickly, consuming a lot of oxygen, but tumors usually have irregular or insufficient vasculature. “So, that creates these pockets of hypoxia—low oxygen—and that’s where HIF-1 comes into play,” Chen says. 

Protein and Breast Cancer

In normal cells, low oxygen triggers HIF-1 to promote the expression of various target genes. The genes impact blood vessel formation, red blood cell production, and stem cell maintenance, among other processes. Hypoxic cancer cells, however, take advantage of the HIF-1 pathways to promote cell survival, migration, and a stem-like cell population. “These cancer stem cells sustain the cancer and can disseminate to different parts of the body, which can contribute to metastasis,” she says.  

In January, Chen won a Provost’s Undergraduate Research Award. She’s studying how HIF-1 interacts with a little-understood protein called nuclear prelamin A recognition factor (NARF) in breast cancer. Previous studies have shown that NARF expression is induced by hypoxia. They’ve also found it likely plays a role in the enrichment of breast cancer stem cells. Part of her research, she explains, involves “knocking down the NARF gene, exposing cells to either normal oxygen conditions or hypoxia, and testing the effect on stem cell marker expression.”

Chen, who also wants to give a shout-out of thanks to her postdoctoral mentor, Yongkang Yang, is motivated more than ever to pursue molecular oncology. “We have the potential to help so many people through this work,” she says. “There’s still so much to learn. My work in the lab inspires me to pursue an MD-PhD to continue doing basic science research in the future.”